Sequential Skin

@sequential.skin

The world’s first at-home skin health and skin microbiome test ✨ Your Skin Microbiome resource. ✍️
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Weeks posts
Tranexamic acid (TXA) has gained significant attention in skincare for its ability to treat hyperpigmentation by interrupting both pigment formation and pigment driven inflammation. Originally used medically to reduce bleeding, TXA inhibits plasma activity, a pathway recognised as relevant in pigment regulation. Its long clinical history means TXA enters cosmetic skincare with a stronger evidence base than many commonly used brightening ingredients. As its use grows, understanding how TXA performs within real formulations and on different skin types is essential for credible product development.
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2 months ago
Proteomics is the large-scale study of proteins, how they are expressed, modified and interact with the body. In skincare, proteomics is emerging as a powerful tool to understand how products influence skin function at a molecular level. Proteins play an important part in many skin processes and by analysing them, offers a more accurate picture of skin health, deeper than surface level observations alone. Unlike genomics, proteomics captures which proteins are present and active under specific conditions.
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2 months ago
For years, intimate care has relied on pH balancing as a measure of safety. However, pH alone does not protect vaginal ecosystems. Microbiome profiles differ widely between women based on hormones, ethnicity, contraceptive use, hygiene habits and life stage. Even pH-aligned products can still disrupt balance, reduce protective lactobacilli or slow recovery, leading to discomfort or recurring symptoms.
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3 months ago
City living exposes skin to constant, invisible stress such as pollutants, heavy metals and airborne microbes. This exposure changes the behaviour of the skin in terms of 1) how well it tolerates ingredients, 2) how quickly irritation appears, and 3) how long recovery takes after disruption. These changes are not just theoretical, research consistently shows measurable biological differences in pollution-exposed skin.
3 1
3 months ago
The gut and skin are connected through shared metabolic, immune and microbial pathways. When the gut microbiome becomes imbalanced, it can heighten systemic inflammation, worsening visible concerns such as acne, eczema, excess oil, redness and slow healing. Likewise, when the skin barrier is compromised, this can influence gut immune tolerance and increase reactivity to foods or environmental triggers. Rather than operating separately, gut and skin act as interacting ecosystems that influence each other’s stability.
4 0
3 months ago
Many people assume there is a single “healthy” or “perfect” microbiome to aim for, but in reality no two microbiomes are alike. Your skin’s microbiome is shaped by genetics, environment, ethnicity, lifestyle, hormones and even climate. Even people with the same skin type or routine can show distinct microbial profiles. What keeps one person’s skin balanced may do little for another, and in some cases can trigger disruption.
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4 months ago
With LED face masks and light-based skincare rapidly increasing in popularity, light has become a new frontier in skin health. Previously seen as a threat and something that we needed to block or avoid, light is now being seen as therapeutic tool. Yet beyond the visible changes to tone and texture, light also interacts with the skin microbiome. Understanding how different wavelengths influence this ecosystem is key to ensuring that light enhances, rather than harms, our skin’s microbial balance.
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4 months ago
During pregnancy, the skin microbiome undergoes significant shifts. Across the trimesters, both the composition and behaviour of skin bacteria change. Postpartum, the maternal skin microbiome continues to evolve which is influenced by hormonal resets, environmental exposures, and hygiene practices. These shifts can also influence an infant’s earliest microbial encounters, during a critical period of skin development.
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5 months ago
Seborrheic dermatitis (SD) is a common inflammatory skin condition primarily affecting the scalp, face and chest. It appears as red, flaky, greasy patches or plaques and can cause itching and discomfort. It is a non-contagious condition varying in severity, from mild dandruff to persistent inflamed lesions.
3 0
5 months ago
The lips may be a small part of the face, but biologically, they behave in entirely unique ways. As temperatures drop and humidity shifts, your lips feel the change immediately; a reminder of how delicate they are and how much care they truly need.
4 0
5 months ago
Within the skincare sector, Vitamin C has been hailed as an all-round skincare essential product with capabilities of for brightening, antioxidant protection, and collagen support however, its specific effects on the skin microbiome are only beginning to be understood.
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6 months ago
Teeth whitening, or dental bleaching, is a popular cosmetic procedure aimed at lightening teeth colour. Despite its widespread use, the impact of these treatments on the oral microbiome remains underexplored.
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7 months ago