Joe Cohen

Hi 👋 I’m Joe, and I overcame 60+ chronic health conditions through extensive research and self-experimentation. I wasn't the picture of perfect health growing up. My life was a puzzle of debilitating symptoms and no diagnosis. Chronic inflammation, brain fog, fatigue, digestive issues, anxiety, depression – you name it, I had it. After hitting rock bottom, I realized that if I stayed on this path, I would never reach my goals or live the life I dreamed of. It was time for a drastic change in how I approached my health. I took matters into my own hands, becoming a biohacker before I even knew what the term meant. Instead of blindly following common health advice, I embarked on a journey of self-experimentation. I read (literally) thousands of PubMed articles to understand the mechanisms behind my health issues, discovered my genetic weaknesses, and was able to optimize my health 10x better than I ever thought was possible. After a year, I was a new person, full of vitality and health. I had hacked my own genes after months of reading scientific literature and experimenting, but I was very frustrated by the lack of tools to help me on my journey. That's why I decided to develop @selfdecode . I put together a team of highly qualified professionals in science, engineering, genomics, and AI to build this platform, and today, we’re the most accurate direct-to-consumer precision health software on the market providing personalized insights based on your DNA, labs, and lifestyle 🚀 I also started a podcast where I interview world-class health experts and share cutting-edge research and strategies for biohacking your body and brain (The Joe Cohen Show - check it out 😉) Now, it's not just about my journey - it's about empowering you with the tools and knowledge to take control of YOUR health. I'm putting health insights directly into your hands. I’ve done my part, now it’s your turn. Join me on this incredible journey towards optimal health 🧬

Biohacking, can we really stay young forever? Join @kathrynthomasofficial for Young Forever: The Death of Ageing? a brand-new two-part series airing NEXT MONDAY at 9:35pm ⏳ #ForeverYoung

Here's every supplement in my regimen 💊🧬 People always ask what I take — so here's the full and latest list. Yes, all 221 substances. This isn't a recommendation — it's my personal protocol built over years of self-experimentation, genetic & lab testing, and research. Everything is dosed and timed intentionally. This list changes weekly. What questions do you have? Drop them below 👇 #supplements #biohacking #longevity #healthoptimization #selfexperimentation #wellnessjourney #healthstack #probiotics #peptides #nootropics #adaptogens #functionalmedicine #healthspan #antiaging #personalizedhealth

What would you rather?

I fed my entire supplement regimen into @SelfDecode 's AI and asked it to analyze everything against my genetic data.Some of what it flagged:🔴 Remove acetylcarnitine — I have a CPT2 variant that impairs fatty acid transport into mitochondria. Acetylcarnitine pushes MORE substrate toward a broken pathway.🔴 Remove astragaloside IV (50mg) — I was already taking whole astragalus. But concentrated astragaloside IV activates telomerase — and my cancer PRS for prostate is 34x, colorectal 9x. ~90% of these cancers use telomerase reactivation to become immortal. I was supplementing the exact molecular tool they'd need.🟡 Reconsider increasing 17-alpha estradiol — My CYP1B1 GG converts estrogens into mutagenic metabolites faster than normal, and my Phase II clearance can't keep up. More estradiol = more reactive intermediates my body can't detoxify.🟢 Add Thymosin Alpha 1 — I started rapamycin for cancer prevention, but my neutropenia PRS is 98th percentile. Tα1 boosts immune competence through thymic pathways without triggering inflammatory NF-κB signaling.🟢 Add liposomal glutathione — My GSTA4 is knocked out. This enzyme conjugates the most toxic lipid peroxidation product to glutathione for elimination. NAC alone isn't enough.Genetics-guided supplementation isn't about adding more. Sometimes the most important move is removing something that's working against your DNA.#Biohacking #Genomics #PersonalizedMedicine #Supplements #SelfDecode #Longevity #GeneticTesting #PrecisionHealth #Nutrigenomics #HealthOptimization

I almost poisoned myself with a “safe” supplement. Methylene blue. Every biohacker’s new favorite compound. Mitochondrial booster. Brain enhancer. Longevity tool. But I ran it through my DNA first. Turns out at standard doses, combined with my sleep stack, it would’ve triggered serotonin syndrome - a potentially life-threatening drug interaction. Same compound. Totally different risk profile. All because of my genetics. Swipe to see what my DNA said ➡️ The dose that’s safe for me: 0.5mg. The dose most people take: 10-20mg. That’s a 20-40x difference based on genetics alone. Stop dosing supplements based on what a podcaster takes. Your DNA is writing a different prescription. Link in bio to check yours. #methylene blue #biohacking #longevity #genetics #personalizedmedicine

I rejected some of the most popular compounds in biohacking — because they conflict with my genetics. Follistatin? Removes tumor growth suppression. I have 34x prostate cancer risk. Epitalon? Activates telomerase. Tumors use telomerase to become immortal. TB-500? Promotes blood vessel growth that tumors hijack. Meanwhile, compounds nobody hypes went to the top of my list: MOTS-c (#1) — mitochondrial rescue for my broken CPT2 pathway SS-31 (#2) — protects mitochondrial membranes from damage my GSTA4 can't clear ARA 290 (#5) — tissue repair WITHOUT the angiogenesis that feeds cancer My CK (muscle damage marker) went from 807 to 305 after building my stack around my genetics. The lesson isn't "take what I take." The lesson is: your #1 peptide might be my #16. And my #1 might be something you'd reject entirely. Same compound. Different genome. Opposite outcomes. If you're spending money on peptides without knowing your genetics, you're playing darts blindfolded. Start with your genome. Then build your stack. Not the other way around. The era of generic protocols is over. #biohacking #peptides #genetics #MOTSc #personalized #genomics #mitochondria #health #longevity #biohack #selfdecode

I ranked 10 peptides against my full genetic profile. ARA 290 landed at #4 — above compounds most biohackers have never even considered. Here's why it beat out more popular options like TB-500 and BPC-157 👇 The key insight: "What's the best peptide?" is the wrong question. "What's the best peptide for YOUR genetic vulnerabilities?" — that's the one that matters. Stop copying someone else's protocol. Start with your genome. #biohacking #peptides #ARA290 #genetics #genomics #personalized #health #wellness #longevity #biohacker #optimization #science

It’s finally here. AI and SelfDecode are changing the world of health and it seems like science fiction. What we have here is 10X better than anything I’ve seen before. You ask it any question and it knows the answer better than anyone else. We’ve been hacking away at building the most advanced genetic analysis for over 10 years but information overload has progressively become a problem. That problem has turned into a massive advantage with this integration. The amazing thing about our AI integration with genetics and lab testing (via an LLM of your choice - I find Claude the best) is that it literally nails everything that works and doesn’t work for me precisely. I’ve been experimenting for 25 yrs and studying biochemistry and it leaves me in the dust. It explains exactly the mechanism of each answer, which I never would know completely without this. And it shows me things that I didn’t fully realize. Any doctor not using SelfDecode and this AI integration should be fired. If you follow anyone’s blueprint, make sure you ask SelfDecode if it fits you. This works better when you have your whole genome done by SelfDecode. Other companies whole genome won’t work well. We are rapidly developing this to make it even better. The health world is about to change dramatically. Don’t forget to look at the last sentence in the last slide 🤣 DM me to get early access.

When even ChatGPT recognizes how superior our tests are 😌✨ Our best sales rep, hands down.

Magnus vs Bryan Johnson vs Joe Cohen grip strength. Who will win?

MyHeritage, with 10M customers, looked at every provider and realized SelfDecode/Omicsedge is the most cutting edge, so they used us for their service.